Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice.

Characterization of Glycolytic Enzyme Interactions with Murine Erythrocyte Membranes in Wild type and Membrane Protein Knockout Mice Short title for the running head: GLYCOLYTIC ENZYME INTERACTIONS WITH ERYTHROCYTE MEMBRANES

Previous research has shown that glycolytic enzymes (GEs) exist as multi-enzyme complexes on the inner surface of human erythrocyte membranes. Because GE binding sites have been mapped to sequences on the membrane protein, band 3, that are not conserved in other mammalian homologs, the question arose whether GEs can organize into complexes on other mammalian erythrocyte membranes. To address th...

Deletion of histidine decarboxylase (HDC) enhances the antinociceptive effects of orexin A in the central nervous system

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...

Effects of capsaicin in low doses and high doses on the small intestine motor response in wild-type and TRPV1 knockout mice

Deletion of histidine decarboxylase (HDC) enhances the antinociceptive effects of orexin A in the central nervous system

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...

Roles of the Duffy antigen and glycophorin A in malaria infectionand erythrocyte.

We constructed gene knockout mice lacking either the Duffy antigen (Dfy) or glycophorin A (GPA), major glycoproteins that are expressed on erythrocyte membranes, to examine the role of these proteins in malaria infection and erythrocyte. All of the rodent malarias examined proliferated in the erythrocytes of these knockout mice, indicating that neither the Duffy antigen nor GPA has an essential...